MRNA Drugs: A Breakthrough Against Viral Infections

Fast Summary

• Researchers are developing an mRNA-based antiviral that could act as a “universal antiviral,” offering protection against multiple viral infections with just one weekly dose, similar to an asthma inhaler.
• The approach involves delivering mRNAs coding for a selection of 10 proteins triggered by interferon, temporarily boosting the body’s innate immune defenses.
• Tests on human cells infected with viruses like flu and Zika showed promising results, with enhanced viral protection.
• Golden hamsters treated with the mRNA cocktail experienced dramatic reductions in SARS-CoV-2 (COVID-19) viral loads compared to untreated animals.
• Unlike existing antivirals targeting specific viruses, this new method uses combinations of proteins that attack multiple stages of virus replication.
• Delivery methods still require refinement to target specific cell types effectively, which delays its general deployment despite the potential benefits.
• Experts warn that reduced funding for mRNA research in the U.S.could slow progress in this field.