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Now Reading: Structural basis of ZP2-targeted female nonhormonal contraception

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Structural basis of ZP2-targeted female nonhormonal contraception

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U.S.//Discover the latest updates from across the United States, including politics, culture, economy, and trending stories. Stay informed on the key events shaping the nation and the topics everyone’s talking about.
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Structural basis of ZP2-targeted female nonhormonal contraception

IO_AdminUncategorized1 month ago24 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 15, April 2025.
Monoclonal antibody IE-3 prevents mouse fertilization by binding ZP2, a major component of the oocyte-specific zona pellucida (ZP). We show that an IE-3-derived single-chain variable fragment (scFV) is sufficient for blocking fertilization in vitro and …
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