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Now Reading: Downregulation of Nesprin1 by Runx2 deficiency is critical for the development of skeletal laminopathy-like pathology

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Downregulation of Nesprin1 by Runx2 deficiency is critical for the development of skeletal laminopathy-like pathology

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Downregulation of Nesprin1 by Runx2 deficiency is critical for the development of skeletal laminopathy-like pathology

AdminUncategorized1 month ago27 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 15, April 2025.
SignificanceWe identified a new laminopathy-like pathogenesis of cleidocranial dysplasia. Runx2 is a master transcription factor in osteogenesis. However, whether any immature osteoblast population emerges from Runx2-deficient cells is unclear. Single…
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