RNA and DNA Sequencing Uncover Unique Skin Microbiome Profiles

Quick Summary

• Focus: A new skin metatranscriptomics workflow has demonstrated high reproducibility adn the ability to uniformly profile genes and enrich microbial messenger RNAs across different skin sites.
• Utility: The workflow enables identification of active microbial species and their functions in vivo, potentially aiding discovery of biomarkers.
• Published: August 28, 2025, in Nature Biotechnology.
• Referenced studies provide insights into:

– How commensal microbes maintain skin integrity (Uberoi et al., Cell Host Microbe, 2021).
– Mechanisms of exacerbated itch via Staphylococcus aureus proteases (Deng et al., Cell, 2023).
– Multifactorial causes of atopic dermatitis (Weidinger et al., Nat Rev Dis. Primers, 2018).

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