New Antivenom Targets World’s Deadliest Snakes

Quick Summary

• Scientists have developed a promising universal snake antivenom using antibodies derived from a hyperimmune man exposed to venom from deadly snakes.
• Current antivenoms are species-specific and rely on non-human antibodies, which may cause severe allergic reactions.
• The new treatment uses broadly neutralizing human antibodies tested on mice exposed to venom from 19 highly perilous snake species.

– It provided full protection against 13 species, including cobra varieties, tiger snakes, and common taipans.
– Partial protection was observed for the remaining six species, including the common death adder.

• The team used blood from Tim Friede, who had self-administered over 700 venom doses. From his immune memory, they identified two key antibodies (LNX-D09 and SNX-B03) combined with a toxin inhibitor (varespladib) in the antivenom formula.
• Next steps include testing on animals treated at vet clinics in Australia after bites and expanding coverage against vipers.
• Experts express cautious optimism about potential universal applications but seek tests for efficacy against necrosis caused by bites.

campaign=RSS%7CNSNS&utmsource=NSNS&utmmedium=RSS&utm_content=home”>Innovative Antivenom May Work Against World’s Deadliest Snakes