CCMB Scientists Uncover How Cells Change Shape

Fast Summary

• Scientists at the CSIR-Center for Cellular and Molecular Biology (CCMB) in Hyderabad announced a finding regarding how cells adapt internal skeletons to form protrusions,crucial for processes like wound healing,immune response,pathogen defense,and cancer progression.
• The research highlighted the role of actin molecules, which create dynamic meshworks near the cell membrane to push in specific directions for these structural changes.
• led by saikat Chowdhury and PhD scholar Justus Francis at CCMB’s cryogenic electron microscope facility,the study identified that a protein called SPIN90 partners with Arp2/3 to enable protrusions by reshaping cells effectively.
• Observations were made with nearly atomic resolution and published in Nature Structural & Molecular Biology.

Indian Opinion Analysis
The breakthrough by CCMB researchers marks an vital step in understanding cellular behavior at fine molecular levels. By identifying SPIN90’s mechanism alongside Arp2/3 complexes, science gains clearer insights into cell remodeling associated with health conditions like cancer progression or tissue repair. This knowledge could contribute to advances across biomedical fields such as diagnostics or therapeutics targeting cellular mechanisms directly linked to disease states affecting millions globally.

India’s ability to deliver impactful scientific research from institutions like CCMB demonstrates growing innovation capacity within biological sciences-a promising indicator of furthering global contributions while strengthening domestic efforts toward improving healthcare outcomes.

For more details: published – September 16, 2025 12:56 am IST