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Now Reading: Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain

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Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain

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Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain

AdminUncategorizedYesterday4 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 20, May 2025.
SignificanceThe oncogenic fusion protein, EWS::FLI1, responsible for more than 85% of Ewing sarcoma tumors combines the transactivation domain from EWS and the DNA-binding domain (DBD) from Friend leukemia integration 1 (FLI1). The fusion impacts the …
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