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Now Reading: Activation mechanism of small heat shock protein HSPB5 revealed by disease-associated mutants

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Activation mechanism of small heat shock protein HSPB5 revealed by disease-associated mutants

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U.S.//Discover the latest updates from across the United States, including politics, culture, economy, and trending stories. Stay informed on the key events shaping the nation and the topics everyone’s talking about.
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Activation mechanism of small heat shock protein HSPB5 revealed by disease-associated mutants

AdminUncategorized2 days ago4 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 20, May 2025.
SignificanceSmall heat shock proteins (sHSPs) are ancient protein chaperones, but how they recognize misfolding proteins in early stages of aggregation is unknown. Disordered regions within sHSPs are critical to their function, raising the question of how …
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