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Now Reading: Activation dynamics of ubiquitin-specific protease 7

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Activation dynamics of ubiquitin-specific protease 7

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Activation dynamics of ubiquitin-specific protease 7

IO_AdminUncategorized3 days ago12 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 21, May 2025.
SignificanceUbiquitin-specific protease 7 (USP7), a deubiquitinating enzyme linked to cancers and neurodevelopmental disorders, adopts an inactive ground conformation and requires substrate binding for activation. Using NMR and enzyme kinetic analyses, we …
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