GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake | Science

AdminUncategorized7 hours ago5 Views

The melanocortin system centrally regulates energy homeostasis, with key components such as melanocortin-4 receptor (MC4R) and adenylyl cyclase 3 (ADCY3) in neuronal primary cilia. Mutations in MC4R and ADCY3 as well as ciliary dysfunction lead to …
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