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Now Reading: Tumor-promoting UBR4 coordinates impaired mitophagy–associated senescence and lung adenocarcinoma pathogenesis

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Tumor-promoting UBR4 coordinates impaired mitophagy–associated senescence and lung adenocarcinoma pathogenesis

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Tumor-promoting UBR4 coordinates impaired mitophagy–associated senescence and lung adenocarcinoma pathogenesis

AdminUncategorized23 hours ago4 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 25, June 2025.
SignificanceOur study identifies a role of UBR4 in regulating mitochondrial quality, cellular aging, and tumor growth in lung adenocarcinoma (LUAD). UBR4 enables mitophagy to maintain healthy mitochondria and support stress adaptation. Loss of UBR4 causes …
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