Volumetric imaging using a distributed molecular network

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Nature Biotechnology

(2025)Cite this article

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We introduce volumetric DNA microscopy, a technique that enables three-dimensional imaging of tissue morphology and gene expression in a single measurement. This feat is achieved by forming a huge intermolecular network of DNA barcodes within an intact specimen and encoding their pairwise proximities into a DNA sequence library.

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Fig. 1: Volumetric DNA microscopy.

References

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This is a summary of: Qian, N. & Weinstein, J. A. Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02613-z (2025).

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Volumetric imaging using a distributed molecular network.
Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02640-w

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  • DOI: https://doi.org/10.1038/s41587-025-02640-w

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