New Tuberculosis Vaccine Shows Promise to Treat Bladder Cancer
Immunotherapy is an innovative way to harness the power of the body’s immune system to fight threats like cancer. Normally, our immune system can detect and destroy abnormal cells on
20101Articles
How Can Seals Hold Their Breath for an Hour or More?
If you could choose one superpower from the animal kingdom, many people might wish for the ability to breathe underwater. Marine ecosystems have long fascinated humans, leading to the development
Sinorhizobium meliloti FcrX coordinates cell cycle and division during free-living growth and symbiosis by a ClpXP-dependent mechanism
Proceedings of the National Academy of Sciences, Volume 122, Issue 11, March 2025. SignificanceDuring the nitrogen-fixing symbiosis between the alphaproteobacteriumSinorhizobium melilotiand the plantMedicago sativa(alfalfa), the interplay of molecular mechanisms governing
SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRASG12D inhibitor in KRAS LUAD
Proceedings of the National Academy of Sciences, Volume 122, Issue 11, March 2025. SignificanceOur data demonstrate the absence of overt toxicity and the therapeutic efficacy of the specific SOS1 inhibitor
Brain-wide dynamic coactivation states code for hand movements in the resting state
Proceedings of the National Academy of Sciences, Volume 122, Issue 11, March 2025. SignificanceThe brain at rest replays activity patterns observed during task performance, but the function of this replay
Characterization of diverse Cas9 orthologs for genome and epigenome editing
Proceedings of the National Academy of Sciences, Volume 122, Issue 11, March 2025. SignificanceCRISPR-based technologies have broadly enabled genome editing over the past decade, however, current approaches are disproportionately based
iPSCs engrafted in allogeneic hosts without immunosuppression induce donor-specific tolerance to secondary allografts
Proceedings of the National Academy of Sciences, Volume 122, Issue 11, March 2025. SignificanceThe immunological properties of induced pluripotent stem cells (iPSCs) during allogeneic transplantation have not yet been fully
High-dimensional imaging using combinatorial channel multiplexing and deep learning
References Rodriguez-Canales, J., Eberle, F. C., Jaffe, E. S. & Emmert-Buck, M. R. Why is it crucial to reintegrate pathology into cancer research? Bioessays 33, 490–498 (2011). Article PubMed PubMed
Leveraging base excision repair for efficient adenine base editing of mitochondrial DNA
Data availability Targeted deep sequencing data, whole-transcriptome sequencing data and whole-genome sequencing data can be accessed from the the National Center for Biotechnology Information under BioProjects PRJNA1223321, PRJNA1221787 and PRJNA1221509.
Lengthy delays in H5N1 genome submissions to GISAID
Real-time surveillance of viral genomes enables the detection of new variants, the assessment of their impact on infectivity and disease severity, the estimation of rates of spread and routes of
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