Autophagy Drives AXL and TIM-1 Downregulation, Sustaining Zika Virus Infection

Speedy Summary

• Publication: Proceedings of the National Academy of Sciences, volume 122, Issue 21, May 2025.
• Topic: Zika virus (ZIKV) infection and its association with severe birth defects.
• Study Focus: The inquiry centers on phosphatidylserine (PS) receptors-specifically AXL receptor tyrosine kinase-and their role in ZIKV pathogenesis.
• Objective: to enhance understanding of the mechanisms behind ZIKV’s effects on human health.

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Indian Opinion Analysis

The study touches upon critical advancements in uncovering mechanisms underlying the severe birth defects caused by Zika virus infections. Although India has not faced a meaningful outbreak of this virus to date, global studies like this one can serve as valuable resources for strengthening preventive frameworks and medical readiness within the country. With increasing globalization and climate change fueling mosquito-borne diseases globally, research focused on viral pathogenesis may help Indian scientists align efforts toward early detection and control strategies in case similar infections emerge within its borders.