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Base editors model mitochondrial disease
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Gene editing
(2025)Cite this article
Subjects
Optimized TALE base editors are used to generate a rat model of mitochondrial disease and then revert the disease mutation in the next generation.
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Competing interests
J.B. is a part owner of a patent covering the use of TALEs.
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Cite this article
Buchholz, P., Boch, J. Base editors model mitochondrial disease.
Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02706-9
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Published:
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DOI: https://doi.org/10.1038/s41587-025-02706-9
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