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Now Reading: Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

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Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

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Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

kisded kisdedUncategorized2 weeks ago26 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 19, May 2025.
SignificanceThe development of small molecule KRAS inhibitors has proven to be a challenge. Recent clinical development of covalent KRAS G12C inhibitors demonstrates the potential of targeting KRAS oncogenic proteins directly. Compounds that target the …
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