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Now Reading: BRAF oncogenic mutants evade autoinhibition through a common mechanism | Science

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BRAF oncogenic mutants evade autoinhibition through a common mechanism | Science

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BRAF oncogenic mutants evade autoinhibition through a common mechanism | Science

BRAF oncogenic mutants evade autoinhibition through a common mechanism | Science

AdminUncategorizedYesterday6 Views

Uncontrolled activation of the rat sarcoma (RAS)–extracellular signal–regulated kinase (ERK) pathway drives tumor growth, often because of oncogenic BRAF mutations. BRAF regulation, involving monomeric autoinhibition and activation by dimerization, has …
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