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Red-shifted chemigenetic biosensors enable sensitive, multiplexed detection of intracellular signaling in living cells across various subcellular compartments and microscopy setups.
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Acknowledgements
The authors thank I. Chen and M. Phelps for constructive comments. We acknowledge support from the St. Jude’s Collaborative Research Consortium on G protein-coupled receptors (M.M.B.) and ALSAC (K.N., V.D.T. and M.M.B.).
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Nemec, K., Trivedi, V.D. & Babu, M.M. Chemigenetic kinase biosensors illuminate cell signaling networks.
Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02672-2
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DOI: https://doi.org/10.1038/s41587-025-02672-2
