Cyclic Peptides Act as Molecular Glues to Stabilize Gq/11 Proteins

Quick Summary

• Heterotrimeric G proteins are molecular switches vital for controlling cellular responses to external signals.
• The study discusses the importance of small molecules, like FR900359 (FR), which selectively inhibit these proteins.
• These inhibitors play a crucial role in understanding the functions and therapeutic potential of G proteins.
• Published in Proceedings of the National Academy of sciences, Volume 122, Issue 19, May 2025.

Indian Opinion Analysis
The research on heterotrimeric G proteins and selective inhibitors like FR900359 is notable for global biomedical science and could have implications for Indian medical innovation and drug development. India has a growing pharmaceutical sector deeply engaged in cutting-edge research, especially targeting diseases with high unmet medical needs. Tools such as FR900359 may help Indian scientists understand cellular mechanisms better, leading to breakthroughs in targeted therapies or precision medicine. As India continues striving toward addressing public health challenges domestically and globally, advancements described in this work underline opportunities for collaboration between Indian institutions and international scientific communities.

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