Database of All Life Extension Interventions

A primary focus of LEV Foundation’s work is to empirically demonstrate the feasibility and value of the divide-and-conquer approach to treating age-related disease – that is, the simultaneous deployment of therapies that independently address the distinct classes of damage that accumulate in aging bodies. With a steadily increasing number of such therapies now showing benefits in both pre-clinical and clinical studies, there is an urgent need to determine which combinations can already yield synergistic benefits in living organisms.

In partnership with Ichor Life Sciences, they are conducting large-scale mouse lifespan studies of such therapeutic mixtures.

the first study of combination of treatments

The second study will have the four treatments and also rapamycin and exercise wheels. So exercise and rapamycin is a baseline treatment for all longevity combinations.

RAID – Rodent Aging Interventions Database RAID provides a visual representation of the extension in lifespan achieved during published interventional studies in normally-aging rodents (mice and rats).

The RAID project arose as a result of work conducted during late 2022 in preparation for the first study in LEV Foundation’s Robust Mouse Rejuvenation (RMR) program: specifically, a comprehensive survey conducted by LEVF’s Chief Science Monitor, Maximus Peto, of publications documenting successful lifespan extension in strains of rodents (mice and rats) with normal baseline lifespans. That survey played an important role in informing the selection of interventions for RMR-1.
Recognising that this compilation of data may be of interest to other researchers in the field of longevity/aging research, we decided to make it publicly available. To enable convenient exploration of the results, we have also developed a visualization tool which depicts the increases in lifespan achieved in different studies as a single bar chart.

Scope
The dataset queried by this tool is intended to cover all published studies that meet the inclusion criteria:

Species: Mice (Mus musculus) or rats (Rattus norvegicus);
Genetic background consistent with normal aging rates (e.g. no progeria, PolG (mtDNA) mutator, Alzheimer’s models such as APP/PS1, etc.);
Reports an intervention with some statistically significant effect on average or maximum lifespan.

It is LvEF intention to update the dataset periodically, but some newer (or recently identified) publications may not yet be indexed; please see below for a list of currently-known exceptions.