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The reported changes within US scientific policy under President Trump could bear ripple effects for nations globally, including India. Historically dependent on collaborations with American institutions for advanced research exchanges and critical technologies, India may face challenges if these cutbacks hinder shared projects or reduce grant availability. With ambitions like Atmanirbhar Bharat (self-reliant India) emphasizing indigenous R&D efforts, such developments underscore India’s need for sustained investment in local science-driven innovation while diversifying international partnerships beyond conventional allies. As global science pivots toward option hubs amid uncertainty in US policy direction, India’s role can be influential if maneuvered judiciously with strategic initiatives prioritizing collaborative growth.