GH13 Enzymes: Key to Fungal Cell Wall Architecture Through α-Glucan Remodeling

Quick Summary:

• The Proceedings of the National Academy of Sciences (PNAS), Volume 122, Issue 29, July 2025, highlights research on fungal cell walls.
• researchers identified two conserved α-amylase-like enzymes, Aah1 and Aah3, which substantially contribute to α-glucan remodeling.
• Fungal cell walls are central for growth, division, survival and are key targets for antifungal therapy advancement.

Indian Opinion Analysis:
The identification of enzymes like Aah1 and Aah3 in fungal research represents a significant advancement in global scientific efforts toward developing effective antifungal therapies.For India-a country where fungal infections such as Candida auris or invasive aspergillosis present serious public health challenges-this study could have impactful implications. In the long-term, leveraging findings from such studies might enable Indian pharmaceutical industries to develop cost-effective treatments that address both domestic and international needs for combating resistant fungal infections.

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