Hdac1 as an early determinant of intermediate-exhausted CD8+ T cell fate in chronic viral infection

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Proceedings of the National Academy of Sciences, Volume 122, Issue 19, May 2025.
SignificanceCD8+T cells are cytotoxic immune cells that are essential for clearing pathogens and malignantly transformed cells but enter an exhausted, hypofunctional state when exposed to persistent stimulation. Here, we demonstrate that histone …
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