Human Telomerase Structure Unveiled: Cryo-EM Reveals Dimerization via H/ACA RNP

Speedy Summary

• Telomerase ribonucleoprotein (RNP) is responsible for synthesizing telomeric repeats at chromosome ends.
• Human telomerase consists of a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR).
• Previous studies indicated that human telomerase is typically monomeric.

Indian Opinion Analysis
Teh implications of advancements in understanding the structural biology of human telomerase coudl resonate in India’s biotechnology, pharmaceutical, and medical research sectors. Given India’s growing focus on healthcare innovation and its large pool of expertise, such breakthroughs can pave the way for deeper exploration into aging mechanisms and treatments for age-related diseases-issues increasingly relevant due to India’s demographic shift toward an aging population. Strengthening investment in related research may help Indian scientists contribute further to global scientific progress.

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