The rise in cases of amoebic encephalitis highlights significant public health concerns regarding water safety and sanitation. With infections reported across several districts in Kerala-including fatalities-there is growing urgency for systematic monitoring and remediation of potential contaminated freshwater sources. Effective coordination between health departments and local infrastructure authorities could mitigate risks associated with waterborne diseases like this. The involvement of state legislative instruments such as invoking the Public Health Act demonstrates proactive measures; however, sustained awareness campaigns will be crucial to preventing further outbreaks. this situation also underscores the need for expanded research into rare infectious diseases that have sporadic but severe impacts.