# Modified Vitamin B12 Compound Crosses Brain Barrier in Rat Cancer Study 2026-08-06T14:50:23+00:00 | Health & Science | Indian Opinion Desk Corroboration: 1 independent outlet A modified vitamin B12 compound has crossed the blood-brain barrier and accumulated in glioblastoma cells in rats, according to research published in Oncoscience, The Hindu reports. The compound, nitrosylcobalamin or NO-Cbl, carries nitric oxide and targets CD320 receptors that help cells absorb vitamin B12. Tumour cells retained higher nitrate levels than normal cells 24 hours after treatment. Laboratory tests also found that combining NO-Cbl with temozolomide and TRAIL suppressed tumours more effectively than either treatment alone. The findings are preclinical and do not show that vitamin B12 supplements can treat brain cancer. The researchers describe the work as a pilot translational study. NO-Cbl’s safety and effectiveness in humans must be tested through clinical trials before it can alter treatment. The approach aims to improve drug delivery while limiting damage to healthy tissue. ## Coverage - thehindu.com Tags: brain cancer, cancer research, drug delivery, glioblastoma, vitamin B12 Canonical: https://indianopinion.org/modified-vitamin-b12-compound-crosses-brain-barrier-in-rat-cancer-study/ License: Summary and commentary (c) Indian Opinion, reusable with attribution. Facts belong to the linked sources. Cite: https://indianopinion.org/modified-vitamin-b12-compound-crosses-brain-barrier-in-rat-cancer-study/#story-in-brief Review state: restored archive article, accurate at time of publication, not offered to search indexes.