Molecular insights into human phosphatidylserine synthase 2 and its regulation of SREBP pathways

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Proceedings of the National Academy of Sciences, Volume 122, Issue 20, May 2025.
SignificanceDespite their high homology, the two mammalian phosphatidylserine synthases, Phosphatidylserine synthases 1 and 2 (PSS1 and PSS2), have opposing roles in lipid regulation. While PSS1 inhibition or deficiency reduces phosphatidylserine (PS) …
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