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Now Reading: MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens

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MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens

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MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens

kisded kisdedUncategorized4 days ago11 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 20, May 2025.
SignificanceThe methylthioadenosine phosphorylase (MTAP) gene is recurrently lost in human cancers. A methylthioadenosine (MTA)-directed DNA-encoded library screening strategy was employed to identify MTA-cooperative PRMT5 binders, leading to development …
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