Natural Molecular Glues Unlock Breakthroughs in Tackling ‘Undruggable’ Targets

Speedy Summary

• Category: News
• Published: july 30, 2025
• Author: Megan Cully
• Source Journal: Nature Biotechnology (2025)

This article highlights advancements in drug progress inspired by natural molecular glues. Researchers are focusing on small molecules to target protein-protein interactions with improved tissue specificity and minimized toxicity. These next-gen molecules aim to address what were historically considered ‘undruggable’ targets for precision medicine.

Indian Opinion analysis

the pursuit of next-gen molecular glues presents transformative possibilities for the global pharmaceutical industry, including advancements in India. India’s role as a important player in generic drug production and biotech innovation positions it well to leverage these developments in local healthcare solutions or research collaborations. With rising interest in personalized medicine, adopting such innovations could enhance India’s capacity for disease-specific interventions while aligning it’s pharma sector with cutting-edge global standards.

However, these breakthroughs may also necessitate rigorous R&D investment and policy updates surrounding intellectual property and biotechnology regulations.It remains crucial for indian academia, healthcare systems, and the government to support foundational research partnerships that might disseminate benefits across major demographics quickly.

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