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Now Reading: Nonenzymatic RNA copying with a potentially primordial genetic alphabet

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Nonenzymatic RNA copying with a potentially primordial genetic alphabet

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Nonenzymatic RNA copying with a potentially primordial genetic alphabet

AdminUncategorizedYesterday9 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 21, May 2025.
SignificanceA long-standing challenge in primordial nonenzymatic RNA copying chemistry is the biased incorporation of C and G over A and U due to differences in base pair strength. We hypothesized that 2-thiopyrimidine substitution could help overcome …
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