Nonlinear Sound-Sheet Microscopy: Revealing Cellular Details in Opaque Organs

Quick Summary

• Light-sheet fluorescence microscopy has transformed biological studies by enabling visualization of dynamic cellular processes in 3D.
• Limitations of the technique include light scattering in thick tissue and photobleaching of fluorescent reporters, which restrict its submission to thin or clear samples.

indian Opinion Analysis
Advancements in microscopy hold significant scientific and medical potential for India, notably as the nation invests heavily in biotechnology and healthcare research.Overcoming challenges like light scattering could pave the way for studying complex cellular interactions relevant to disease modeling and drug development, areas critical to improving public health outcomes. Increased access to state-of-the-art technologies such as light-sheet fluorescence microscopy can bolster India’s global competitiveness in scientific innovation.

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