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Developers are recombining or sharpening established drugs, molecules and mechanisms to create a new generation of neurology therapies.
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Harrison, C. Nat. Biotechnol. 43, 287–289 (2025).
McDermott, L. A. et al. Neuron https://doi.org/10.1016/j.neuron.2019.01.047 (2019).
Knowland, D. et al. J. Clin. Invest. https://doi.org/10.1172/JCI140311 (2020).
Wieskopf, J. S. et al. Sci. Transl. Med. https://doi.org/10.1126/scitranslmed.3009986 (2015).
Conaghan, P. et al. In ACR Convergence 2024 https://acrabstracts.org/abstract/levi-04-a-novel-neurotrophin-3-inhibitor-substantially-improves-pain-and-function-without-deleterious-effects-on-joint-structure-in-people-with-knee-osteoarthritis-a-randomized-controlled-phase-ii/ (2024).
Zhang, M. et al. Signal Transduct. Target. Ther. https://doi.org/10.1038/s41392-023-01464-x (2023).
Khairatkar-Joshi, N. & Szallasi, A. Trends Mol. Med. https://doi.org/10.1016/j.molmed.2008.11.004 (2009).
Finol-Urdaneta, R. K. et al. Proc. Natl Acad. Sci. USA https://doi.org/10.1073/pnas.2110932119 (2022).
Cao, B. et al. Signal Transduct. Target. Ther. https://doi.org/10.1038/s41392-024-01845-w (2024).
Gahr, M., Kratzer, W., Fuchs, M. & Connemann, B. J. et al. Curr. Drug Metab. https://doi.org/10.2174/1389200215666140926155041 (2014).
Bremova-Ertl, T. et al. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2310151 (2024).
Churchill, G. C., Strupp, M., Galione, A. & Platt, F. M. et al. PLoS One https://doi.org/10.1371/journal.pone.0229585 (2020).
Oertel, W. H. et al. Nat. Commun. https://doi.org/10.1038/s41467-024-51502-7 (2024).
Al-zharani, M., Hasnain, M. S., Al-Eissa, M. S. & Alqahtani, R. A. et al. J. King Saud Univ. Sci. https://doi.org/10.1016/j.jksus.2024.103513 (2024).
Razavi, R., Khajouei, G., Divsalar, F., Dawi, E. & Amiri, M. et al. Rev. Neurosci. https://doi.org/10.1515/revneuro-2024-0086 (2024).
Senior, M. Precision neuroscience.
Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02673-1
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DOI: https://doi.org/10.1038/s41587-025-02673-1