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Now Reading: Proteostasis landscapes of cystic fibrosis variants reveal drug response vulnerability

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Proteostasis landscapes of cystic fibrosis variants reveal drug response vulnerability

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Proteostasis landscapes of cystic fibrosis variants reveal drug response vulnerability

IO_AdminUncategorized4 weeks ago16 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 17, April 2025.
SignificanceCystic fibrosis (CF) is a lethal genetic disease with variants leading to misfolding of an anion channel protein. Enhancing productive channel folding using a novel class of small molecules called correctors has emerged as the current CF …
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