Radical SAM Enzyme Unlocks Diverse Thioether Macrocyclic Peptides

Speedy Summary:

• The Proceedings of the National Academy of Sciences (PNAS) published findings in its August 2025 issue, Volume 122, Issue 34.
• Research highlights a breakthrough in chemical synthesis using the radical S-adenosyl-L-methionine enzyme PapB.
• Traditional methods for creating thioether-containing cyclic peptides are limited due to reliance on preinstalled electrophiles and complex processes.
• The revelation could address scaffold diversity and expand applications in peptide synthesis.

Indian Opinion Analysis:
This scientific advancement represents potential innovation within chemical and pharmaceutical research sectors, both globally and specifically for India. If applied effectively, it may accelerate novel drug growth or enhance biomolecular designs critical for industrial applications. For India-a country with a burgeoning biotech industry-this development offers an opportunity for collaboration with international research institutions to adopt cutting-edge methodologies that can strengthen its market competitiveness in peptide-related innovations.

Read More