Scientists Discover Unexpected Cell Division Mechanism

Speedy Summary

• Scientists have discovered an unexpected form of human cell division that retains information encoded in cell shapes, allowing cells to direct the types of thier offspring.
• Previously, cells were thought to round before dividing symmetrically into identical types, with exceptions like stem cells undergoing asymmetric division.
• Researchers observed endothelial cells in zebrafish blood vessel formation dividing asymmetrically without rounding and noted similar patterns when mimicking these conditions for human endothelial cells in laboratory settings.
• Longer and thinner cell shapes were most likely to divide asymmetrically,enabling dynamic processes like tissue advancement or migration alongside division.
• Applications include engineering tissues resistant to limitations like growing blood vessels and gaining deeper insights into cancer spread dynamics via migrating clusters of mutant cells.

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