SEMA3C from Fibroblasts Linked to Colorectal Cancer Spread to Liver via NRP2-MAPK Pathway

rapid Summary

• The Proceedings of the National Academy of Sciences (PNAS) published findings in volume 122, Issue 21, May 2025.
• Research reveals that liver metastasis is the primary cause of mortality among colorectal cancer (CRC) patients.
• The study identifies gaps in understanding the mechanisms behind CRC liver metastasis initiation adn explores cellular origins related to metastatic progression.

Indian Opinion Analysis
Colorectal cancer treatment and research on liver metastases are critical for advancing healthcare outcomes worldwide, including in India where cancer burden is rising due to lifestyle changes and aging populations. This study’s focus on cellular mechanisms could pave the way for new therapeutic strategies or diagnostic methods if translated into clinical applications globally.For India, greater emphasis on early detection tools and advanced research collaborations may become essential given notable demand for oncological care amid resource constraints.

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