Sialylated IgG: Unveiling Key Molecular Drivers of Anti-Inflammatory Action

Quick Summary

• Research published in Proceedings of the National Academy of Sciences, Volume 122, Issue 20, may 2025 examines the role of terminal sialylation on IgG Fc glycans.
• Findings reveal that subclasses IgG1 and IgG3 exhibit anti-inflammatory activity when sialylated; this effect was not observed in IgG2 or IgG4.
• The anti-inflammatory action of sialylated IgG1 and IgG3 is dependent on type II fc γ receptors in vivo.

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Indian Opinion Analysis
The study could influence medical research in India by presenting novel approaches to addressing inflammation-linked health issues prevalent across various regions. With growing concerns over autoimmune diseases and inflammatory disorders within an aging population, these insights into immunoglobulin subclasses’ mechanisms offer opportunities for therapeutic advancements. Indian scientists and policymakers may consider collaborating internationally to incorporate these findings into healthcare strategies while promoting domestic research capacities in immunology for long-term benefits.