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Now Reading: Spinal TRPC3 promotes neuropathic pain and coordinates phospholipase C–induced mechanical hypersensitivity

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Spinal TRPC3 promotes neuropathic pain and coordinates phospholipase C–induced mechanical hypersensitivity

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Spinal TRPC3 promotes neuropathic pain and coordinates phospholipase C–induced mechanical hypersensitivity

IO_AdminUncategorized3 months ago44 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 11, March 2025.
SignificanceHere, we demonstrate the pathophysiological role of TRPC3 in the development of neuropathic pain using TRPC3-knockout mice. TRPC3 deficiency suppressed pain hypersensitivity in a neuropathic pain mouse model. TRPC3 is mainly expressed in the …
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