Study Reveals How SARS-CoV-2 nsp15 Weakens Host Antiviral Defenses

Fast summary

• The Proceedings of the National Academy of Sciences (PNAS), Volume 122, Issue 24, June 2025, discusses findings related to SARS-CoV-2.
• Researchers studied how the virus employs multiple strategies to evade human antiviral defenses.
• These evasion mechanisms can lead to severe outcomes for individuals, including pneumonia adn death.

Indian Opinion Analysis
Understanding how SARS-CoV-2 bypasses human immune defenses is crucial for global health efforts and pandemic preparedness. For India, this research underscores the importance of continued vigilance in biomedical investigations and healthcare infrastructure development to address future variants or similar pathogens effectively. As one of the nations deeply impacted by earlier COVID-19 waves, such studies provide key insights that could strengthen India’s public health policy framework while emphasizing preventive measures against severe disease outcomes.

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