Study Traces Decline in Yersinia pestis Virulence Across Three Plague Pandemics

IO_AdminUncategorized1 month ago68 Views

Quick Summary

  • Yersinia pestis, the bacterium responsible for plague, has historically caused three major pandemics after spilling over from wild rodent reservoirs to commensal rodents and humans.
  • Scientific findings highlight a depletion in the copy number of the plasmid-encoded virulence gene “pla” in later-dated strains of Yersinia pestis.

Indian Opinion Analysis
The study underscores how genetic evolution in pathogens like Yersinia pestis impacts their virulence and pandemic potential. Understanding this adaptive process offers valuable insights into historical pandemics and might inform future preparedness against similar zoonotic diseases in India. India’s focus on public health infrastructure and advanced genomic research collaborations coudl play a critical role in mitigating risks from emerging pathogens linked to wildlife or rodents, especially given its diverse ecosystems that host varied species prone to spillovers.

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