The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes

kisded kisdedUncategorized2 weeks ago47 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 19, May 2025.
SignificanceDysregulated Wnt signaling is a well-established driver of colorectal carcinogenesis. However, its pivotal role in normal intestinal stem cell homeostasis has posed significant challenges for its therapeutic inhibition, highlighting the need …
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