Unraveling mantATP Turnover in Skinned Muscle Fibers: A Study Combining Experiments and Computation

Quick Summary

• The Proceedings of the National Academy of Sciences, Volume 122, Issue 20 (May 2025), features a study discussing myosin resting states and their role in muscle contractility and basal metabolism.
• The mantATP chasing technique is highlighted as a widely used method to evaluate nucleotide turnover in myosin’s Super Relaxed State.

Indian Opinion Analysis
This research potentially offers valuable insights into molecular biology that could impact India’s growing scientific community and health sector.Muscle contractility studies may open avenues for advancing treatments for metabolic and muscular disorders prevalent in India. Additionally, knowledge from such work might contribute to India’s efforts in scientific innovation around healthcare by fostering collaboration between researchers at domestic institutions and international platforms like PNAS.

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