Unveiling How Excitatory Amino Acid Transporter 3 Recognizes Substrates

Quick Summary:

• The Proceedings of the National Academy of Sciences (PNAS), Volume 122, Issue 16 (April 2025), examined EAAT3, a human excitatory amino acid transporter.
• EAAT3 pumps L-glutamate, L-aspartate, and L-cysteine into cells using ion gradients.
• Dysfunction in EAAT3 is linked too neurological pathologies and its activation has been observed in certain cancers.

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Indian Opinion Analysis:
Understanding EAAT3’s mechanism and its dual role in neurological diseases and cancer provides pivotal insight for Indian researchers working on global health challenges like neurodegenerative disorders or oncology treatments. Addressing this issue could pave the way for novel therapies that benefit millions of Indians affected by such conditions each year. Expanding collaboration between Indian laboratories and international institutions like PNAS could considerably amplify contributions to these critical fields-bridging gaps between research potential and outcomes while boosting India’s leadership role in medical science innovations globally.