Wegovy’s Higher Dose: Greater Weight Loss, Increased Side Effects

Fast Summary

• A higher weekly dose of Wegovy (7.2 mg vs. the standard 2.4 mg) results in greater weight loss but brings an increased risk of side effects.
• Trial results show:

– Standard dose group lost 16% body weight on average, while the high-dose group lost about 19%.
– Placebo group recorded only a 4% average weight loss.

• Prediabetes cases were reduced by:

– 83% in the high-dose group.- 74% in the standard-dose group.

• Gut-related side effects like nausea and vomiting occurred in:

– 61% (standard dose).
– 71% (high dose).

• Dysesthesia (painful skin sensations) affected over one-fifth of participants in the higher-dose trial, with four discontinuing treatment due to discomfort.
• The study hints at potential benefits for patients seeking greater health improvements but emphasizes that further trials are needed.